性别

    女

  出生年月

    1993.03

  职称

    特聘副教授

  学历（学位）

    博士

  所属院系

    必威体育官网

  导师类别

    硕士生导师

  行政职务

   光电传感与生命分析教育部重点实验室党支部书记

  招生专业

    化学，分析化学，应用化学

  研究方向

    生化分析，单分子检测

  联系方式

     lichenchen@qust.edu.cn

CCE大楼805

个人简历（包括近期科研项目）

工作和教育经历：

2020/09 - 至今，青岛科技大学，必威体育官网，特聘副教授

2015/09 - 2020/06，山东师范大学，分析化学，博士

2011/09 - 2015/06，山东师范大学，化学，学士

2020年毕业于山东师范大学，获理学博士学位。致力于肿瘤标志物超灵敏检测的生物传感器研究，发展了一系列基于单分子检测、荧光检测、化学发光检测的生物传感器，并将其成功应用于检测各种 DNA、microRNA、蛋白质、酶和肿瘤细胞。以第一作者/并列一作在 Chemical Science、Analytical Chemistry、 Biosensors & Bioelectronics、 Chemical Communications、 Trends in Analytical Chemistry 等国际权威杂志发表 SCI 论文30余篇。申请国家发明专利12项。获第十四届青岛市青年科技奖。

主持科研项目:

山东省优秀青年基金、国家自然科学基金青年项目、山东省自然科学基金青年项目、山东省精细化学品清洁工程重点实验室开放课题、青岛科技大学科研启动基金。

承担教学课程：

本科生：《基础化学原理实验》；研究生：《实验室安全》。

代表性论文：

1. Li, C. C.; Chen, H. Y.; Luo, X.; Hu, J.; Zhang, C. Y., Multicolor fluorescence encoding of different microRNAs in lung cancer tissues at the single-molecule level. Chem. Sci. 2021, 12 (37), 12407-12418.

2. Li, C. C.; Chen, H. Y.; Hu, J.; Zhang, C. Y., Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level. Chem. Sci. 2020, 11 (22), 5724-5734.

3. Li, C. C.; Liu, W. X.; Hu, J.; Zhang, C. Y., A single quantum dot-based nanosensor with multilayer of multiple acceptors for ultrasensitive detection of human alkyladenine DNA glycosylase. Chem. Sci. 2019, 10, 8675-8684.

4. Li, C. C; Liu, W. X.; Jiang, S.; Liu, M.; Luo, X.; Zhang, C. Y.; Construction of Bioluminescent Sensors for Label-Free, Template-Free, Separation-Free, and Sequence-Independent Detection of both Clustered and Isolated Damage in Genomic DNA, Anal. Chem. 2022, 94(42): 14716-14724

5. Li, C. C.; Hu, J.; Zou, X.; Luo, X.; Zhang, C. Y., Construction of a Structure-Switchable Toehold Dumbbell Probe for Sensitive and Label-Free Measurement of MicroRNA in Cancer Cells and Tissues. Anal. Chem. 2022, 94 (3), 1882-1889.

6. Li, C. C.; Hu, J.; Luo, X.; Hu, J.; Zhang, C. Y., Development of a Single Quantum Dot-Mediated FRET Nanosensor for Sensitive Detection of Single-Nucleotide Polymorphism in Cancer Cells. Anal. Chem. 2021, 93 (43), 14568-14576.

7. Li, C. C.; Dong, Y. H.; Zou, X. R.; Luo, X. L.; Shen, D. Z.; Hu, J.; Zhang, C. Y., Label-Free and Template-Free Chemiluminescent Biosensor for Sensitive Detection of 5-Hydroxymethylcytosine in Genomic DNA. Anal. Chem. 2021, 93 (4), 1939-1943.

8. Li, C. C.; Wang, Z. Y.; Wang, L. J.; Zhang, C. Y., Biosensors for epigenetic biomarkers detection: A review. Biosens. Bioelectron. 2019, 144, 111695.

9. Li, C. C.; Hu, J.; Lu, M. F.; Zhang, C. Y., Quantum dot-based electrochemical biosensor for stripping voltammetric detection of telomerase at the single-cell level. Biosens. Bioelectron. 2018, 122, 51-57.

10. Li, C. C.; Zhang, Y.; Tang, B.; Zhang, C. Y., Integration of single-molecule detection with magnetic separation for multiplexed detection of DNA glycosylases. Chem. Commun. 2018, 54 (46), 5839-5842.

11. Li, C. C.; Zhang, Y.; Liu, W. J.; Zhang, C. Y., A triple-amplification strategy for sensitive detection of telomerase at the single-cell level. Chem. Commun. 2018, 54 (67), 9317-9320.

12. Li, C. C.; Li, Y; Zhang, Y.; Zhang, C. Y., Single-molecule fluorescence resonance energy transfer and its biomedical applications. Trends Anal. Chem. 2020, 122, 115753.

13. 李琛琛，陈慧燕，董月红，罗细亮，胡娟，张春阳，表观遗传修饰——5-羟甲基胞嘧啶检测的研究进展. 化学学报 2021, 79 (5), 614-627.

14. Zhang, Y.; Li, C. C.; Zhang, X.; Xu, Q.; Zhang, C. Y., Development of Oxidation Damage Base-Based Fluorescent Probe for Direct Detection of DNA Methylation. Anal. Chem. 2020, 92 (15), 10223-10227.

15. Zhang, Y., Li, C. C.; Tang, B.; Zhang, C. Y., Homogeneously Sensitive Detection of Multiple DNA Glycosylases with Intrinsically Fluorescent Nucleotides. Anal. Chem. 2017, 89 (14), 7684-7692.

16. Ma, F.; Li, C. C.; Zhang, C. Y., Nucleic acid amplification-integrated single-molecule fluorescence imaging for in vitro and in vivo biosensing. Chem. Commun. 2021, 57 (99), 13415-13428.

17. Ma, F.; Li, C. C.; Zhang, C. Y., Development of quantum dot-based biosensors: principles and applications. J. Mater. Chem. B 2018, 6 (39), 6173-6190.

18. Cui, L.; Li, C. C.; Tang, B.; Zhang, C. Y., Advances in the integration of quantum dots with various nanomaterials for biomedical and environmental applications. Analyst 2018, 143 (11), 2469-2478.

19. Wang, L. J.; Han, X.; Li, C. C.; Zhang, C. Y., Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase. Chem. Sci. 2018, 9 (28), 6053-6061.

20. Zhang, Y.; Li, Q. N.; Li, C. C.; Zhang, C. Y., Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification. Chem. Commun. 2018, 54 (51), 6991-6994.